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KMID : 0191120120270080883
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Journal of Korean Medical Science
2012 Volume.27 No. 8 p.883 ~ p.889
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Coexistence of Chronic Lymphocytic Thyroiditis with Papillary Thyroid Carcinoma: Clinical Manifestation and Prognostic Outcome
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Jeong Jun-Soo
Kim Hyun-Ki
Lee Cho-Rok
Park Seul-kee
Park Jae-Hyun
Kang Sang-Wook
Jeong Jong-Ju
Nam Kee-Hyun
Chung Woong-Youn
Park Cheong-Soo
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Abstract
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The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence
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KEYWORD
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Chronic Lymphocytic Thyroiditis, Papillary Thyroid Carcinoma, Recurrence, Prognostic Outcome
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